Description
General Description
DSPE-PEG-OPSS is a functional phospholipid derivative designed for membrane anchoring and thiol-specific bioconjugation. The DSPE segment efficiently inserts into lipid bilayers, liposomes, lipid nanoparticles (LNPs), micelles, and other lipid-based delivery systems. The PEG spacer extends into the aqueous environment, improving colloidal stability, reducing steric hindrance, and minimizing nonspecific interactions.
The terminal orthopyridyl disulfide (OPSS) group readily reacts with free sulfhydryl groups on peptides, proteins, antibodies, enzymes, thiolated oligonucleotides, and nanoparticles through disulfide exchange chemistry. The reaction releases pyridine-2-thione and forms a disulfide bond between the lipid conjugate and the target molecule. DSPE-PEG-OPSS is frequently used in targeted delivery systems, immunoliposomes, redox-responsive nanocarriers, and advanced nanomedicine applications.
Applications
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Antibody conjugation
- Protein conjugation
- Peptide conjugation
- Thiolated oligonucleotide conjugation
- Surface modification
- Targeted drug delivery
- Redox-responsive nanoparticles
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Reactive OPSS functionality
- Efficient thiol-specific conjugation
- Forms cleavable disulfide linkages
- Hydrophilic PEG spacer
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
