Description
General Description
DMPE-mPEG is a phospholipid–poly(ethylene glycol) conjugate containing DMPE (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, C14:0) and a methoxy-terminated PEG chain. The DMPE lipid anchor enables stable incorporation into lipid bilayers, while the PEG spacer improves aqueous stability, steric stabilization, and biocompatibility.
Key Properties
- Methoxy-terminated lipid PEG conjugate
- DMPE phospholipid anchor (C14:0)
- PEG spacer improves hydrophilicity and circulation stability
- Biocompatible lipid–polymer hybrid material
- Suitable for liposome and nanoparticle stabilization
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) engineering
- PEGylation and steric stabilization
- Drug delivery system development
- Nanomedicine and biomaterial engineering
- Surface modification of lipid-based systems
Functional Overview
The DMPE lipid segment anchors into lipid bilayers, while the methoxy PEG chain forms a hydrophilic corona that reduces aggregation, improves colloidal stability, and enhances biocompatibility.
Summary
DMPE-mPEG is a versatile PEGylated phospholipid widely used in liposome formulation, lipid nanoparticle stabilization, and advanced drug delivery applications.
