Description
General Description
DOPE-PEG-Maleimide, DOPE-PEG-MAL is an amphiphilic lipid-polymer conjugate composed of a hydrophobic DOPE lipid anchor, a hydrophilic PEG spacer, and a terminal maleimide functional group. The DOPE moiety readily incorporates into lipid bilayers, liposomes, lipid nanoparticles (LNPs), and other lipid-based delivery systems, while the PEG chain provides steric stabilization and improved circulation properties.
The terminal maleimide group selectively reacts with thiol-containing peptides, proteins, antibodies, aptamers, and other biomolecules under mild conditions to form stable thioether bonds. DOPE-PEG-MAL is widely used for the preparation of targeted liposomes, functionalized lipid nanoparticles, diagnostic probes, and drug delivery systems.
Applications
- Liposome surface modification
- Lipid nanoparticle (LNP) functionalization
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein immobilization
- Thiol-maleimide bioconjugation
- Gene delivery systems
- Nanomedicine research
- Diagnostic imaging probes
Features and Benefits
- Reactive maleimide functional group
- Efficient thiol-selective conjugation
- Stable thioether bond formation
- Excellent liposome incorporation
- Amphiphilic lipid-PEG structure
- Improves nanoparticle stability
- Supports targeted delivery applications
- Compatible with peptides, proteins, and antibodies
- Available in various PEG molecular weights
Summary
DOPE-PEG-MAL is a versatile thiol-reactive PEGylated phospholipid widely used in liposome engineering, nanomedicine, and advanced drug delivery applications.
