DOPE-PEG-N3 structure

DOPE-PEG-N₃

Price range: $420.00 through $1,360.00

DOPE-PEG-N3 is an azide-functionalized lipid-PEG conjugate consisting of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), polyethylene glycol (PEG), and a terminal azide group. The DOPE lipid anchor readily incorporates into liposomes and lipid nanoparticles, while the azide functionality enables efficient click chemistry conjugation with alkyne- and DBCO-containing molecules. DOPE-PEG-N3 is widely used in liposome engineering, lipid nanoparticle functionalization, targeted drug delivery, molecular imaging, and nanomedicine research.

Product Specifications

Product Name: DOPE-PEG-N3
Full Name: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-Polyethylene Glycol-Azide
Molecular Weight: PEG 1k, 2k, 3.4k, 5k, 10k Da
Functional Groups: DOPE, PEG, Azide (N3)
Appearance: White to off-white solid
Solubility: Water, PBS, Chloroform, Methanol, DMSO, DMF
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

DOPE-PEG-N3 structure

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Description

General Description

DOPE-PEG-N₃ is a phospholipid–poly(ethylene glycol) conjugate containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1), a hydrophilic PEG spacer, and a terminal azide functional group. The azide group enables selective bioorthogonal conjugation through click chemistry reactions with alkyne-containing molecules.

Key Properties

  • Azide-functionalized PEG phospholipid
  • Suitable for click chemistry reactions (CuAAC / SPAAC)
  • DOPE phospholipid anchor (C18:1)
  • Unsaturated fusogenic lipid structure
  • PEG spacer improves aqueous stability and biocompatibility

Applications

  • Liposome and lipid nanoparticle functionalization
  • Click chemistry bioconjugation
  • Drug and nucleic acid delivery
  • Surface modification of nanoparticles and biomaterials
  • Targeted nanomedicine applications
  • Hydrogel and biomaterial engineering

Functional Overview

The DOPE lipid segment supports membrane fusion and endosomal escape, while the PEG spacer improves steric stabilization and circulation behavior. The terminal azide group enables selective conjugation with alkyne-functionalized molecules through click chemistry reactions.

Summary

DOPE-PEG-N₃ is a versatile click-functional PEGylated phospholipid widely used in liposome engineering, nanomedicine, and advanced drug delivery applications.

Additional information

Molecular Weight

1000, 2000, 3400, 5000
Package Size

100mg, 200mg, 500mg, 1g

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