Description
General Description
DSPE-Aldehyde (DSPE-ALD) is a reactive lipid building block designed for the functionalization of lipid-based delivery systems. The DSPE component contains two saturated stearoyl (C18:0) lipid chains that provide strong hydrophobic anchoring into lipid bilayers, liposomes, and lipid nanoparticles.
The terminal aldehyde group reacts readily with primary amines to form Schiff base linkages, which can be stabilized through reductive amination to generate stable secondary amine bonds. Aldehyde groups also react efficiently with hydrazide and aminooxy-functionalized molecules to form hydrazone and oxime linkages, enabling attachment of peptides, proteins, antibodies, targeting ligands, polymers, and imaging probes.
DSPE-Aldehyde combines the excellent membrane stability of DSPE with versatile aldehyde chemistry, making it useful for preparing targeted liposomes, functional nanoparticles, biosensors, diagnostic agents, and advanced nanomedicine platforms.
Applications
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Protein conjugation
- Antibody attachment
- Peptide conjugation
- Targeted drug delivery
- Molecular imaging
- Biosensor development
- Surface modification
- Biomaterials research
Features and Benefits
- Reactive aldehyde functionality
- Stable DSPE lipid anchor
- Efficient amine conjugation
- Compatible with hydrazone and oxime chemistry
- Strong membrane incorporation
- Suitable for liposomes and LNPs
- Enables ligand attachment
- Useful for targeted delivery applications
