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DSPE (1,2-Distearoyl-sn-glycero-3-phosphoethanolamine) is a saturated phospholipid containing two stearic acid (C18:0) lipid chains and a phosphoethanolamine head group. DSPE is widely used for liposome preparation, lipid nanoparticles (LNPs), membrane research, drug delivery systems, and as a building block for functional PEG-lipids such as DSPE-PEG derivatives.
| CAS No. : | 816-94-4 |
| Formula : | C44H88NO8P |
| M.W : | 790.15 |
| SMILES Code : | O=P(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)([O-])OCC[N+](C)(C)C |
| Synonyms : |
1,2-Distearoyl-sn-glycero-3-PC; DSPC; Coatsome MC 8080
|
| English Name : | (R)-2,3-Bis(stearoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate |
| MDL No. : | MFCD00036905 |
| InChI Key : | NRJAVPSFFCBXDT-HUESYALOSA-N |
| Pubchem ID : | 94190 |
DSPE is a synthetic phospholipid extensively used in pharmaceutical formulation, nanotechnology, and biomaterials research. The molecule consists of two saturated C18 stearoyl hydrocarbon chains attached to a glycerophosphoethanolamine backbone, providing excellent membrane stability and structural integrity.
Due to its high phase transition temperature and saturated lipid chains, DSPE contributes to the formation of stable lipid bilayers and improves the mechanical stability of liposomes and lipid-based nanoparticles. The primary amine-containing phosphoethanolamine head group can also serve as a reactive site for further chemical modification, enabling the synthesis of functional phospholipids including DSPE-PEG, DSPE-PEG-Maleimide, DSPE-PEG-Biotin, DSPE-PEG-NHS, and other targeted lipid conjugates.
DSPE and DSPE-based derivatives are widely employed in liposomal drug delivery, vaccine formulations, nucleic acid delivery systems, diagnostic imaging, membrane studies, and advanced nanomedicine applications.
| Package Size | 100mg, 200mg, 500mg, 1g, 5g |
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