Description
General Description
DSPE-Alkyne is a reactive phospholipid designed for membrane incorporation and click chemistry-based bioconjugation. The hydrophobic DSPE segment efficiently inserts into lipid bilayers, liposomes, lipid nanoparticles (LNPs), micelles, and other lipid-based delivery systems. The terminal alkyne group provides a versatile bioorthogonal handle for conjugation with azide-functionalized molecules through copper-catalyzed azide-alkyne cycloaddition (CuAAC) and related click chemistry reactions.
Due to its small size and excellent stability, the alkyne functionality minimally affects membrane properties while providing an efficient platform for attaching peptides, proteins, antibodies, fluorophores, nucleic acids, polymers, and targeting ligands. DSPE-Alkyne is frequently employed in nanoparticle engineering, targeted drug delivery, molecular imaging, and advanced biomaterials research.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Click chemistry conjugation
- Surface modification
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Molecular imaging
- Targeted drug delivery
- Nanomedicine research
Features and Benefits
- DSPE phospholipid anchor
- Reactive terminal alkyne functionality
- Compatible with click chemistry reactions
- Efficient bioorthogonal conjugation
- Stable under physiological conditions
- Minimal impact on membrane properties
- Suitable for liposomes and LNPs
- Enables versatile surface functionalization
- Widely used in nanomedicine applications
