Description
General Description
DSPE-DBCO is a click-reactive lipid designed for efficient modification of lipid-based delivery systems. The DSPE lipid anchor contains two saturated stearoyl (C18:0) hydrocarbon chains that provide stable insertion into lipid bilayers, liposomes, and lipid nanoparticles.
The terminal DBCO group reacts selectively with azide-functionalized molecules through strain-promoted azide-alkyne cycloaddition (SPAAC), enabling copper-free click chemistry under mild physiological conditions without requiring catalysts. This reaction allows convenient attachment of targeting ligands, peptides, antibodies, polymers, fluorescent probes, and other biomolecules.
DSPE-DBCO provides a simple strategy for post-functionalization of lipid nanoparticles, liposomes, and membrane surfaces. It is widely used for targeted nanomedicine, molecular imaging probes, biosensors, and advanced lipid-based biomaterials.
Applications
- Copper-free click chemistry (SPAAC)
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Azide-containing molecule conjugation
- Antibody attachment
- Peptide conjugation
- Targeted drug delivery
- Molecular imaging
- Biosensor fabrication
- Biomaterials research
Features and Benefits
- Reactive DBCO functionality
- Stable DSPE lipid anchor
- Copper-free azide click chemistry
- Efficient membrane incorporation
- Suitable for liposomes and LNPs
- Enables ligand attachment
- Bioorthogonal conjugation
- Useful for targeted delivery applications
