Description
General Description
DSPE-PEG-VS is a functional phospholipid derivative designed for membrane anchoring and thiol-selective bioconjugation. The DSPE segment efficiently inserts into lipid bilayers, liposomes, lipid nanoparticles (LNPs), micelles, and other lipid-based delivery systems. The PEG spacer extends into the aqueous environment, improving colloidal stability, reducing steric hindrance, and minimizing nonspecific interactions.
The terminal vinyl sulfone group reacts readily with sulfhydryl-containing peptides, proteins, antibodies, enzymes, and thiolated oligonucleotides through Michael addition chemistry under mild conditions. Compared with maleimide groups, vinyl sulfone functionalities often provide enhanced hydrolytic stability and highly stable thioether linkages. DSPE-PEG-VS is frequently used for targeted delivery systems, immunoliposomes, nanoparticle engineering, and advanced nanomedicine applications.
Applications
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Antibody conjugation
- Protein conjugation
- Peptide conjugation
- Thiolated oligonucleotide conjugation
- Surface modification
- Targeted drug delivery
- Nanoparticle engineering
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Reactive vinyl sulfone functionality
- Efficient thiol-selective conjugation
- Forms stable thioether linkages
- Greater hydrolytic stability than some maleimide derivatives
- Hydrophilic PEG spacer
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
