Description
General Description
HS-PEG-SH is a versatile homobifunctional PEG linker designed for thiol-mediated conjugation and crosslinking applications. The two terminal thiol groups provide reactive sites for coupling with proteins, peptides, antibodies, nanoparticles, polymers, and biomaterial surfaces.
The hydrophilic PEG spacer improves water solubility, flexibility, biocompatibility, and reduces nonspecific protein adsorption. The terminal thiol groups readily participate in thiol-maleimide coupling, thiol-ene reactions, disulfide exchange reactions, and gold surface immobilization.
HS-PEG-SH is frequently employed in hydrogel fabrication, nanoparticle stabilization, biosensor preparation, self-assembled monolayers (SAMs), surface modification, drug delivery systems, and advanced biomaterials development.
Applications
- Hydrogel synthesis
- Thiol-maleimide conjugation
- Thiol-ene chemistry
- Nanoparticle functionalization
- Gold nanoparticle modification
- Surface immobilization
- Biosensor fabrication
- Drug delivery systems
- Biomaterials engineering
- Biomedical research
Features and Benefits
- Two terminal thiol groups
- Homobifunctional PEG linker
- Excellent water solubility
- Compatible with thiol-maleimide chemistry
- Suitable for thiol-ene reactions
- Gold surface binding capability
- Excellent biocompatibility
- Flexible molecular spacer
- Available in multiple molecular weights
