Description
General Description
Lipoic acid-PEG-Amine (LA-PEG-NH2) is a versatile heterobifunctional PEG linker designed for nanoparticle surface engineering and bioconjugation. The terminal lipoic acid contains a cyclic disulfide that forms strong sulfur-metal interactions with gold nanoparticles, gold electrodes, and other noble metal surfaces, providing greater stability than many monothiol-based surface ligands.
The terminal primary amine readily reacts with activated carboxylic acids through EDC/NHS coupling, as well as NHS esters, aldehydes, epoxides, isothiocyanates, and other amine-reactive functional groups to form stable covalent linkages.
The hydrophilic PEG spacer enhances water solubility, molecular flexibility, and biocompatibility while reducing steric hindrance and minimizing nonspecific protein adsorption. Lipoic Acid-PEG-NH2 is widely employed in biosensor fabrication, gold nanoparticle functionalization, protein and antibody conjugation, molecular imaging, targeted drug delivery, and advanced biomaterials development.
Applications
- Gold nanoparticle functionalization
- Gold surface modification
- Biosensor fabrication
- Protein conjugation
- Antibody conjugation
- Surface PEGylation
- Nanoparticle engineering
- Drug delivery systems
- Molecular imaging
- Biomaterials research
Features and Benefits
- Stable lipoic acid gold anchor
- Terminal primary amine
- Efficient amine conjugation
- Strong gold surface binding
- Excellent water solubility
- Excellent biocompatibility
- Reduced nonspecific protein adsorption
- Versatile heterobifunctional PEG linker
- Available in multiple PEG molecular weights
