Description
General Description
mPEG-Succinimidyl Carbonate (mPEG-SC) is a highly reactive linear monofunctional PEG reagent designed for efficient amine-selective PEGylation. The terminal methoxy group is chemically inert, preventing polymer crosslinking, while the succinimidyl carbonate group serves as an activated carbonate for rapid conjugation with primary amines.
The activated succinimidyl carbonate reacts readily with proteins, peptides, antibodies, enzymes, amino-containing polymers, nanoparticles, and other biomolecules under mild aqueous conditions (typically pH 7.5–9.0), forming stable carbamate (urethane) linkages. Compared with NHS esters, the resulting carbamate bond is often more resistant to hydrolysis, making mPEG-SC a preferred reagent for many therapeutic PEGylation applications.
The PEG spacer enhances aqueous solubility, improves biocompatibility, reduces nonspecific protein adsorption, and prolongs circulation time in vivo. mPEG-SC is widely employed for therapeutic protein PEGylation, enzyme modification, antibody conjugation, nanoparticle surface engineering, hydrogel preparation, and advanced biomedical research.
Applications
- Protein PEGylation
- Enzyme modification
- Antibody conjugation
- Peptide conjugation
- Drug conjugation
- Nanoparticle functionalization
- Surface modification
- Hydrogel synthesis
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Linear monofunctional PEG reagent
- Activated succinimidyl carbonate functionality
- Rapid amine-selective conjugation
- Stable carbamate (urethane) bond formation
- Excellent aqueous stability after conjugation
- Excellent water solubility
- Excellent biocompatibility
- Available in multiple PEG molecular weights
