Description
General Description
mPEG-Aldehyde (mPEG-ALD) is a versatile monofunctional PEG reagent designed for site-selective bioconjugation and PEGylation. The terminal methoxy group is chemically inert, preventing polymer crosslinking, while the terminal aldehyde group provides a highly reactive handle for conjugation with biomolecules.
The aldehyde group reacts with primary amines to form Schiff bases, which can be stabilized by reductive amination to generate stable secondary amine linkages. It also reacts efficiently with hydrazide- and aminooxy-containing compounds to form hydrazone and oxime bonds under mild conditions. These reactions enable efficient conjugation of proteins, peptides, antibodies, enzymes, nanoparticles, and small molecules.
The PEG spacer enhances aqueous solubility, improves biocompatibility, reduces nonspecific protein adsorption, and prolongs circulation time in vivo. mPEG-ALD is widely used for therapeutic protein PEGylation, drug conjugation, diagnostic reagent development, nanoparticle surface modification, and biomedical research.
Applications
- Protein PEGylation
- Peptide conjugation
- Antibody modification
- Enzyme PEGylation
- Drug conjugation
- Nanoparticle functionalization
- Surface modification
- Diagnostic reagent development
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Monofunctional PEG reagent
- Reactive aldehyde functionality
- Suitable for reductive amination
- Compatible with hydrazone and oxime ligation
- Excellent water solubility
- Excellent biocompatibility
- Reduces nonspecific protein adsorption
- Available in multiple PEG molecular weights
