Description
General Description
mPEG-Alkyne (mPEG-ALK) is a versatile monofunctional PEG reagent designed for bioorthogonal conjugation and PEGylation applications. The terminal methoxy group is chemically inert, preventing polymer crosslinking, while the terminal alkyne group serves as a highly selective reactive handle for click chemistry.
The terminal alkyne readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules, producing stable triazole linkages with excellent efficiency and specificity. This reaction enables conjugation with proteins, peptides, antibodies, nucleic acids, nanoparticles, polymers, fluorescent dyes, and targeting ligands.
The PEG spacer improves aqueous solubility, enhances biocompatibility, reduces nonspecific protein adsorption, and prolongs circulation time in vivo. mPEG-ALK is widely employed in protein PEGylation, click chemistry, nanoparticle surface modification, molecular imaging, drug delivery systems, and biomedical research.
Applications
- Click chemistry (CuAAC)
- Protein PEGylation
- Peptide conjugation
- Antibody modification
- Drug conjugation
- Nanoparticle functionalization
- Surface modification
- Molecular imaging
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Monofunctional PEG reagent
- Terminal alkyne functionality
- Compatible with CuAAC click chemistry
- Highly selective bioorthogonal conjugation
- Excellent water solubility
- Excellent biocompatibility
- Reduces nonspecific protein adsorption
- Available in multiple PEG molecular weights
