Description
General Description
Acrylate-PEG-NHS is a versatile heterobifunctional PEG reagent designed for orthogonal bioconjugation and hydrogel fabrication. The terminal NHS ester reacts rapidly with primary amines on proteins, peptides, antibodies, enzymes, and other biomolecules under mild aqueous conditions, forming stable amide bonds.
The terminal acrylate group is compatible with free-radical polymerization and readily undergoes Michael addition with thiol-containing molecules. This combination allows sequential conjugation of biomolecules followed by incorporation into polymer networks or hydrogels, making Acrylate-PEG-NHS an ideal building block for tissue engineering scaffolds, injectable hydrogels, surface coatings, and targeted drug delivery systems.
The hydrophilic PEG spacer enhances water solubility, molecular flexibility, and biocompatibility while minimizing nonspecific protein adsorption.
Applications
- Hydrogel synthesis
- Protein conjugation
- Antibody conjugation
- Peptide conjugation
- Tissue engineering
- Injectable hydrogels
- Surface modification
- Drug delivery systems
- Polymer synthesis
- Biomaterials research
Features and Benefits
- Heterobifunctional PEG linker
- Reactive acrylate functionality
- Reactive NHS ester
- Efficient amine-specific conjugation
- Compatible with Michael addition
- Compatible with free-radical polymerization
- Excellent water solubility
- Excellent biocompatibility
- Available in multiple PEG molecular weights
