N3-PLL

N3-Poly(L-Lysine) (N3-PLL)

Price range: $380.00 through $600.00

N₃-Poly(L-Lysine) (N₃-PLL) is an azide-functionalized cationic polypeptide composed of poly(L-lysine) with a terminal azide (N₃) group. The azide functionality enables highly efficient click chemistry with alkyne- and DBCO-containing molecules, while the poly(L-lysine) backbone contains multiple primary amine groups for nucleic acid complexation and chemical modification. N₃-PLL is widely used in gene delivery, click chemistry, nanoparticle engineering, hydrogel synthesis, and biomaterials research.

Product Name: N₃-Poly(L-Lysine)
Alternative Name: N₃-PLL, Azide-Poly(L-Lysine), Azide-PLL
Molecular Weight: Custom
Degree of Polymerization: Custom
Functional Groups: Terminal Azide (N₃), Multiple Primary Amines
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS, aqueous buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

N3-PLL

 

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SKU: 9093 Categories: , , ,

Description

General Description

N3-Poly(L-Lysine) (N3-PLL) is a functional cationic polypeptide designed for bioorthogonal conjugation and advanced drug delivery applications. The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN, enabling highly selective conjugation under mild conditions.

The poly(L-lysine) backbone contains numerous primary amine groups that electrostatically interact with negatively charged nucleic acids, including DNA, RNA, siRNA, and mRNA. These amine groups also react with NHS esters, activated carboxylic acids, aldehydes, epoxides, and other amine-reactive molecules, providing versatile opportunities for further functionalization.

N₃-PLL is extensively employed in gene delivery, polymer-drug conjugates, nanoparticle functionalization, hydrogel preparation, surface engineering, molecular imaging, and advanced biomaterials research.

Applications

  • Click chemistry (CuAAC)
  • Copper-free click chemistry (SPAAC)
  • Gene delivery
  • DNA and RNA complexation
  • Nanoparticle functionalization
  • Surface modification
  • Hydrogel synthesis
  • Drug conjugation
  • Molecular imaging
  • Biomaterials research

Features and Benefits

  • Terminal azide functionality
  • Compatible with CuAAC click chemistry
  • Compatible with SPAAC chemistry
  • Multiple primary amine groups
  • Excellent nucleic acid binding
  • Excellent aqueous solubility
  • Biodegradable polypeptide
  • Available in multiple molecular weights

Additional information

Molecular weight

3000 (m=20), 7500 (m=50)
Package size

50mg, 100mg

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