Description
General Description
NH2-PEG-COOtBu is a versatile heterobifunctional PEG linker designed for stepwise synthetic modification. The terminal amine group readily reacts with NHS esters, activated carboxylic acids, aldehydes, isocyanates, and other electrophilic reagents, allowing efficient attachment to biomolecules and synthetic intermediates.
The tert-butyl ester serves as a protected carboxylic acid functionality that remains stable under most coupling conditions and can be selectively removed under acidic conditions to generate a free carboxyl group. This orthogonal reactivity makes NH2-PEG-COOtBu a valuable intermediate for the synthesis of multifunctional PEG derivatives, targeted drug conjugates, polymer therapeutics, and advanced biomaterials.
Applications
- PEGylation
- Linker synthesis
- Drug conjugation
- Peptide conjugation
- Protein conjugation
- Antibody modification
- Polymer synthesis
- Surface modification
- Biomaterials research
- Bioconjugation
Features and Benefits
- Heterobifunctional PEG linker
- Reactive primary amine functionality
- Protected carboxylic acid group
- Orthogonal functional group chemistry
- Selective tert-butyl deprotection
- Excellent aqueous solubility
- Flexible PEG spacer
- Suitable for multi-step synthesis
- Available in multiple PEG molecular weights
