Description
General Description
PCL-PEG-COOH is a functional biodegradable copolymer designed for nanoparticle engineering and biomedical applications. The hydrophobic PCL segment forms the core of nanoparticles and micelles capable of encapsulating hydrophobic drugs, proteins, peptides, and imaging agents, while the PEG segment forms a hydrophilic corona that enhances colloidal stability and reduces nonspecific protein adsorption.
The terminal carboxylic acid group serves as a versatile reactive handle for conjugation with amines, peptides, proteins, antibodies, fluorophores, and targeting ligands through carbodiimide-mediated coupling chemistry. PCL-PEG-COOH is frequently used in targeted drug delivery systems, tissue engineering scaffolds, hydrogel preparation, and advanced biomaterials development.
Applications
- Drug delivery systems
- Nanoparticle formulation
- Polymeric micelle preparation
- Controlled drug release
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Tissue engineering
- Surface modification
- Biomaterials research
Features and Benefits
- Biodegradable PCL segment
- Hydrophilic PEG spacer
- Reactive carboxylic acid functionality
- Excellent biocompatibility
- Improves nanoparticle stability
- Reduces protein adsorption
- Suitable for bioconjugation
- Supports sustained drug release
- Available in multiple molecular weights
