PLGA-Amine (PLGA-NH2, 85:15)

PLGA-Amine (PLGA-NH2, 85:15)

Price range: $100.00 through $360.00

PLGA-Amine (PLGA-NH2, 85:15) is a biodegradable poly(lactide-co-glycolide) copolymer with an 85:15 lactide ratio and a terminal primary amine (NH2) group. The terminal amine provides a versatile reactive site for bioconjugation and chemical modification, while the high lactide content affords slower degradation and prolonged drug release. PLGA-NH2 (85:15) is widely used in sustained drug delivery, nanoparticle formulation, tissue engineering, and biomaterials research.

Product Name: PLGA-Amine (PLGA-NH2, 85:15)
Alternative Name: Amino-Terminated PLGA (85:15), PLGA-NH2 (85:15)
Polymer Type: Poly(D,L-lactide-co-glycolide)
Lactide Ratio: 85:15
Molecular Weight: 2k, 5k, 10k, 15k, 20k, 30k, 50k, 100k Da, Custom
End Group: Primary Amine (NH2)
Appearance: White to off-white powder or solid
Solubility: Dichloromethane, Chloroform, THF, Acetone, DMF, DMSO
Storage: -20°C, dry and protected from moisture
Purity: Typically ≥95%

 

Request Bulk Quote? Request Custom Synthesis?
SKU: 12429 Categories: , ,

Description

General Description

PLGA-Amine (PLGA-NH2, 85:15) is an amino-terminated biodegradable polyester composed of 85% lactide and 15% glycolide. Compared with PLGA 50:50 and 75:25, the higher lactide content increases polymer hydrophobicity and slows hydrolytic degradation, making it particularly suitable for long-term controlled drug release and implantable biomedical applications.

The terminal primary amine readily reacts with activated carboxylic acids, NHS esters, aldehydes, epoxides, isothiocyanates, and other amine-reactive molecules. It can also be used to prepare PEGylated PLGA, antibody-polymer conjugates, peptide-polymer conjugates, fluorescent polymers, and targeted drug delivery systems.

PLGA-Amine (85:15) is extensively employed in nanoparticles, microspheres, injectable depots, implantable drug delivery devices, tissue engineering scaffolds, biodegradable implants, and advanced biomaterials development.

Applications

  • Sustained drug delivery
  • Long-acting injectable formulations
  • Nanoparticle formulation
  • Microsphere preparation
  • PEG conjugation
  • Protein conjugation
  • Antibody conjugation
  • Tissue engineering
  • Surface modification
  • Biomedical research

Features and Benefits

  • Terminal primary amine functionality
  • 85:15 lactide composition
  • Slower degradation profile
  • Extended drug release
  • Excellent biocompatibility
  • Versatile bioconjugation chemistry
  • Excellent drug encapsulation capability

Additional information

Molecular weight

5000, 10K, 20K, 40K
Package size

100mg, 1g

Related products