PLGA-PEG-NH2

PLGA-PEG-NH2

Price range: $300.00 through $1,060.00

PLGA-PEG-NH2, PLGA-PEG-amine is a biodegradable amphiphilic block copolymer consisting of poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), and a terminal primary amine group. The PLGA segment enables drug encapsulation and controlled release, the PEG spacer improves aqueous solubility and biocompatibility, and the amine functionality provides a versatile reactive site for conjugation with biomolecules and targeting ligands. PLGA-PEG-NH2 is widely used in drug delivery, nanoparticle functionalization, biomaterials engineering, and nanomedicine research.

Product Specifications

Product Name: PLGA-PEG-NH2
Polymer Composition: Poly(lactic-co-glycolic acid)-Polyethylene Glycol-Amine
Molecular Weight: PLGA (2k-50k), PEG (1k, 2k, 3.4k, 5k, 10k Da), Custom
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Functional Groups: PLGA, PEG, Amine (NH2)
Appearance: White to off-white solid
Solubility: DMSO, DMF, Acetone, THF, Dichloromethane, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PLGA-PEG-NH2
SKU: 2758 Categories: , ,

Description

General Description

PLGA-PEG-NH2 is a functional biodegradable copolymer designed for nanoparticle formulation and bioconjugation applications. The hydrophobic PLGA segment forms the core of nanoparticles and micelles capable of encapsulating hydrophobic drugs, proteins, peptides, and imaging agents, while the PEG segment forms a hydrophilic corona that enhances colloidal stability and reduces nonspecific protein adsorption.

The terminal primary amine group serves as a versatile reactive handle for conjugation with activated esters, carboxylic acids, aldehydes, isocyanates, fluorophores, peptides, antibodies, proteins, and targeting ligands. PLGA-PEG-NH2 is frequently used in targeted drug delivery systems, polymer therapeutics, imaging agents, tissue engineering scaffolds, and advanced biomaterials.

Applications

  • Drug delivery systems
  • Nanoparticle formulation
  • Polymeric micelle preparation
  • Antibody conjugation
  • Peptide conjugation
  • Protein conjugation
  • Targeted drug delivery
  • Surface modification
  • Tissue engineering
  • Nanomedicine research

Features and Benefits

  • Biodegradable PLGA segment
  • Hydrophilic PEG spacer
  • Reactive primary amine functionality
  • Excellent biocompatibility
  • Improves nanoparticle stability
  • Reduces protein adsorption
  • Enables versatile bioconjugation
  • Suitable for targeted delivery systems
  • Available in multiple molecular weights

 

 

Additional information

PLGA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10k, 16K, 20K, 30K, 40K
PEG Molecular Weight

1000, 2000, 3000, 5000
Package size

100mg, 1g

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