PLL-g-PEG-Biotin

PLL-g-PEG-Biotin

Price range: $480.00 through $650.00

PLL-g-PEG-Biotin is a biotin-functionalized graft copolymer consisting of poly(L-lysine) (PLL) and polyethylene glycol (PEG) side chains terminated with biotin groups. The PLL backbone provides multiple cationic amino groups for nucleic acid binding and surface adsorption, while the PEG chains improve biocompatibility, water solubility, and reduce nonspecific interactions. The terminal biotin functionality enables high-affinity binding to streptavidin and avidin. PLL-g-PEG-Biotin is widely used in gene delivery, surface modification, biosensors, targeted delivery systems, and biomaterials research.

Product Specifications

Product Name: PLL-g-PEG-Biotin
Polymer Composition: Poly(L-lysine)-graft-Polyethylene Glycol-Biotin
Molecular Weight: Custom
PLL Degree of Polymerization: Custom
PEG Molecular Weight: 1k, 2k, 3.4k, 5k, 10k Da
PEG Grafting Density: Custom
Functional Groups: PLL, PEG, Biotin
Appearance: White to off-white solid
Solubility: Water, PBS, Aqueous Buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

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SKU: 11835 Categories: , , , ,

Description

General Description

PLL-g-PEG-Biotin is a multifunctional graft copolymer designed for targeted bioconjugation and biomedical applications. The poly(L-lysine) backbone contains multiple primary amine groups that facilitate electrostatic interaction with nucleic acids, proteins, cell membranes, and negatively charged surfaces. Grafted PEG chains provide steric stabilization, enhanced aqueous solubility, improved biocompatibility, and reduced protein adsorption.

The terminal biotin groups enable highly specific binding to streptavidin, avidin, and neutravidin, allowing efficient immobilization of proteins, antibodies, peptides, enzymes, nanoparticles, fluorophores, and targeting ligands. PLL-g-PEG-Biotin is frequently employed in gene delivery systems, biosensor fabrication, cell-surface engineering, molecular diagnostics, and advanced biomaterials development.

Applications

  • Gene delivery
  • DNA delivery
  • mRNA delivery
  • siRNA delivery
  • Surface modification
  • Biosensor development
  • Streptavidin-mediated immobilization
  • Nanoparticle functionalization
  • Molecular diagnostics
  • Tissue engineering

Features and Benefits

  • Poly(L-lysine) backbone
  • PEG graft architecture
  • Terminal biotin functionality
  • High-affinity streptavidin binding
  • Excellent water solubility
  • Reduced protein adsorption
  • Improved biocompatibility
  • Efficient surface functionalization
  • Suitable for gene delivery applications

Additional information

PLL repeating units

100, 150, 200
Molecular weight of PEG

2000, 3400
Percentage of PEG substitution

10%, 20%, 30%
Package size

50mg, 100mg

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