PLL-g-PEG-N3

PLL-g-PEG-N3

Price range: $460.00 through $650.00

PLL-g-PEG-N3 is an azide-functionalized graft copolymer consisting of poly(L-lysine) (PLL) and polyethylene glycol (PEG) side chains terminated with azide groups. The PLL backbone provides multiple cationic amino groups for nucleic acid binding and surface adsorption, while the PEG chains improve biocompatibility, water solubility, and reduce nonspecific interactions. The terminal azide functionality enables efficient click chemistry conjugation with alkyne- and DBCO-containing molecules. PLL-g-PEG-N3 is widely used in gene delivery, surface modification, biomaterials engineering, and nanomedicine research.

Product Specifications

Product Name: PLL-g-PEG-N3
Polymer Composition: Poly(L-lysine)-graft-Polyethylene Glycol-Azide
Molecular Weight: Custom
PLL Degree of Polymerization: Custom
PEG Molecular Weight: 1k, 2k, 3.4k, 5k, 10k Da
PEG Grafting Density: Custom
Functional Groups: PLL, PEG, Azide (N3)
Appearance: White to off-white solid
Solubility: Water, PBS, Aqueous Buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

Request Bulk Quote? Request Custom Synthesis?
SKU: 11862 Categories: , , ,

Description

General Description

PLL-g-PEG-N3 is a multifunctional graft copolymer designed for bioorthogonal conjugation and biomedical applications. The poly(L-lysine) backbone contains multiple primary amine groups that facilitate electrostatic interaction with nucleic acids, proteins, cell membranes, and negatively charged surfaces. Grafted PEG chains provide steric stabilization, improved aqueous solubility, enhanced biocompatibility, and reduced protein adsorption.

The terminal azide groups readily participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, enabling attachment of peptides, proteins, antibodies, fluorophores, nanoparticles, nucleic acids, and targeting ligands. PLL-g-PEG-N3 is frequently employed in gene delivery systems, surface coatings, biosensors, tissue engineering, and advanced biomaterials.

Applications

  • Gene delivery
  • DNA delivery
  • mRNA delivery
  • siRNA delivery
  • Click chemistry conjugation
  • Surface modification
  • Biomaterial coatings
  • Biosensor development
  • Nanoparticle functionalization
  • Tissue engineering

Features and Benefits

  • Poly(L-lysine) backbone
  • PEG graft architecture
  • Reactive azide functionality
  • Compatible with CuAAC and SPAAC chemistry
  • Excellent water solubility
  • Reduced protein adsorption
  • Improved biocompatibility
  • Efficient surface functionalization
  • Suitable for gene delivery applications

Additional information

PLL repeating units

100, 150, 200
Molecular weight of PEG

2000, 3400, 5000
Percentage of PEG substitution

20%, 30%
Package size

50mg, 100mg

Related products