Trityl-PEG-PLL structure

PLL-PEG-Tritylthiol (PLL-PEG-Trt-SH)

Price range: $460.00 through $1,600.00

PLL-PEG-Tritylthiol (PLL-PEG-Trt-SH) is a block copolymer consisting of poly(L-lysine) (PLL) and polyethylene glycol (PEG) with a terminal trityl-protected thiol (Trt-SH) group. The trityl group protects the thiol during synthesis and storage and can be readily removed under mild acidic conditions to generate a free thiol for subsequent bioconjugation. PLL-PEG-Tritylthiol is widely used in drug delivery, nanoparticle preparation, hydrogel synthesis, surface modification, and biomaterials research.

Product Name: PLL-PEG-Tritylthiol
Alternative Name: PLL-PEG-Trt-SH, PLL-PEG-Trityl-Protected Thiol
PEG Molecular Weight: Custom
PLL Degree of Polymerization: Custom
Functional Groups: Poly(L-lysine), PEG, Terminal Trityl-Protected Thiol (Trt-SH)
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS, aqueous buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

Trityl-PEG-PLL structure

 

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SKU: 28273-8274 Categories: , , ,

Description

General Description

PLL-PEG-Tritylthiol is a biodegradable block copolymer designed for the preparation of thiol-functional biomaterials and nanocarriers. The polymer combines the cationic properties of poly(L-lysine) with the hydrophilicity and biocompatibility of PEG, while the terminal trityl-protected thiol provides a stable, protected reactive handle for downstream functionalization.

Following deprotection, the free thiol readily participates in thiol-maleimide conjugation, thiol-ene click chemistry, disulfide bond formation, Michael addition, and gold surface immobilization. The poly(L-lysine) segment contains multiple primary amine groups that enable electrostatic interaction with nucleic acids and can also be chemically modified using NHS esters, activated carboxylic acids, aldehydes, and other amine-reactive reagents.

PLL-PEG-Tritylthiol is widely employed in gene delivery, polymer-drug conjugates, hydrogel preparation, nanoparticle surface engineering, biosensors, tissue engineering, and advanced biomaterials research.

Applications

  • Gene delivery
  • Nucleic acid delivery
  • Thiol-functional polymer synthesis
  • Nanoparticle functionalization
  • Hydrogel synthesis
  • Surface modification
  • Drug conjugation
  • Gold nanoparticle functionalization
  • Tissue engineering
  • Biomaterials research

Features and Benefits

  • Block copolymer architecture
  • Terminal trityl-protected thiol
  • Easily deprotected to free thiol
  • Multiple primary amines on PLL
  • Excellent water solubility
  • Excellent biocompatibility
  • Suitable for post-polymer functionalization
  • Available in various PLL lengths and PEG molecular weights

Additional information

MW of PLL

3300(X=20), 8,200 (X=50), 16,000 (X=100), 32,000 (X=200)
MW of PEG

1000, 2000, 3400, 5000
Pakage size

100mg, 200mg, 500mg

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