PLLA-PEG-OPSS

Price range: $380.00 through $1,200.00

PLLA-PEG-OPSS is a biodegradable amphiphilic block copolymer composed of poly(L-lactide) (PLLA), polyethylene glycol (PEG), and a terminal orthopyridyl disulfide (OPSS) group. The OPSS functionality reacts selectively with thiol-containing molecules through disulfide exchange, enabling conjugation of peptides, proteins, antibodies, and other thiolated molecules. PLLA-PEG-OPSS is widely used for functionalized nanoparticles, targeted drug delivery, reversible bioconjugation, and biomaterials research.

Product Name: PLLA-PEG-OPSS
Alternative Names: PLLA-PEG-Orthopyridyl Disulfide; PLLA-PEG-Pyridyl Disulfide; OPSS-PEG-PLLA; Poly(L-lactide)-PEG-OPSS
Polymer Structure: Poly(L-lactide)-Polyethylene Glycol-Orthopyridyl Disulfide
Polymer Architecture: AB Diblock Copolymer
PLLA Molecular Weight: Custom available
PEG Molecular Weight: Custom available
Functional Group: Orthopyridyl Disulfide (OPSS)
Reactive Partner: Thiol (–SH)
Conjugation Chemistry: Thiol-Disulfide Exchange
Linkage After Conjugation: Cleavable Disulfide
Appearance: White to off-white solid
Solubility: Chloroform, dichloromethane, THF, DMF, DMSO
Purity: Typically ≥95%

PLA-PEG-opss

Description

her biomaterials requiring reversible thiol conjugation.

Applications

  • Polymeric nanoparticle preparation
  • Polymeric micelle formation
  • Thiol-selective bioconjugation
  • Reversible disulfide conjugation
  • Protein and peptide conjugation
  • Antibody conjugation
  • Targeting ligand attachment
  • Redox-responsive drug delivery
  • Nanoparticle surface functionalization
  • Biomaterials research

Features and Benefits

  • Biodegradable PLLA block
  • Hydrophilic PEG spacer
  • Terminal OPSS functionality
  • Selective reaction with thiols
  • Forms cleavable disulfide bonds
  • Suitable for cysteine-containing biomolecules
  • Useful for redox-responsive conjugates
  • Self-assembly into nanoparticles and micelles
  • Tunable PLLA and PEG molecular weights

 

 

 

Additional information

PLA Molecular Weight

1000, 2000, 3000, 4000, 5000, 10k

PEG Molecular Weight

1000, 2000, 3000, 5000

Package size

100mg, 1g