Description
General Description
tBoc-NH-PEG-OH (Boc-PEG-OH) is a versatile heterobifunctional PEG intermediate designed for controlled organic synthesis and orthogonal functionalization. The terminal Boc-protected amine remains chemically inert under many reaction conditions, allowing selective modification of the hydroxyl terminus without interference from the amine. After synthetic transformations are complete, the Boc group can be removed using acidic reagents such as trifluoroacetic acid (TFA) or hydrochloric acid in dioxane to generate the corresponding primary amine.
The terminal hydroxyl group can be converted into activated esters, carboxylic acids, aldehydes, halides, acrylates, methacrylates, azides, alkynes, or other functional groups, making tBoc-NH-PEG-OH a highly versatile intermediate for preparing heterobifunctional PEG linkers.
The hydrophilic PEG spacer provides excellent water solubility, flexibility, and biocompatibility. tBoc-NH-PEG-OH is widely employed in PEG linker synthesis, polymer chemistry, peptide synthesis, nanoparticle engineering, drug conjugation, and advanced biomaterials development.
Applications
- PEG linker synthesis
- Polymer synthesis
- Peptide synthesis
- Drug conjugation
- Bioconjugation
- Nanoparticle functionalization
- Surface modification
- Hydrogel synthesis
- Biomaterials engineering
- Biomedical research
Features and Benefits
- Boc-protected primary amine
- Terminal hydroxyl group
- Orthogonal functionalization
- Acid-labile protecting group
- Excellent water solubility
- High synthetic versatility
- Excellent biocompatibility
- Ideal PEG intermediate
- Available in multiple PEG molecular weights
