Thiol-Poly(L-lysine)-Thiol (HS-PLL-SH)

Thiol-Poly(L-lysine)-Thiol (HS-PLL-SH)

Price range: $460.00 through $1,600.00

Thiol-Poly(L-lysine)-Thiol (HS-PLL-SH) is a bifunctional poly(L-lysine) derivative containing terminal thiol (SH) groups at both ends of the polymer chain. The thiol groups enable selective conjugation through thiol-maleimide coupling, thiol-ene click chemistry, disulfide formation, and Michael addition reactions, while the poly(L-lysine) backbone provides multiple cationic amine groups for electrostatic interaction with nucleic acids and negatively charged biomolecules. HS-PLL-SH is widely used in gene delivery, hydrogel synthesis, biomaterials engineering, and bioconjugation.

Product Name: Thiol-Poly(L-lysine)-Thiol
Alternative Name: HS-PLL-SH, Poly(L-lysine)-Dithiol
Polymer Backbone: Poly(L-lysine)
Molecular Weight: Custom
Functional Groups: Thiol (SH) × 2, Primary Amines (PLL Side Chains)
Appearance: White to off-white solid
Solubility: Water, PBS, DMSO
Storage: -20°C, dry and protected from moisture
Purity: Typically ≥95%

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SKU: 12570 Categories: , ,

Description

General Description

Thiol-Poly(L-lysine)-Thiol (HS-PLL-SH) is a functional polycation designed for advanced biomaterials and bioconjugation applications. The poly(L-lysine) backbone contains abundant ε-amino groups that readily interact with DNA, RNA, proteins, polysaccharides, and cell membranes through electrostatic interactions, making it an excellent material for nucleic acid delivery and surface modification.

Terminal thiol groups provide versatile reactive handles for conjugation with maleimides, vinyl sulfones, acrylates, norbornenes, activated disulfides, and gold surfaces. These reactions proceed under mild conditions to form stable covalent linkages, enabling the preparation of hydrogels, polymer networks, nanoparticles, and multifunctional biomaterials.

Thiol-Poly(L-lysine)-Thiol combines the excellent biocompatibility and biodegradability of poly(L-lysine) with the versatility of thiol chemistry, making it suitable for drug delivery, tissue engineering, cell encapsulation, biosensors, and regenerative medicine.

Applications

  • Gene delivery
  • DNA and RNA complexation
  • Hydrogel synthesis
  • Thiol-maleimide conjugation
  • Thiol-ene click chemistry
  • Surface modification
  • Nanoparticle functionalization
  • Tissue engineering
  • Drug delivery systems
  • Biomaterials research

Additional information

Molecular weight

3300(X=20), 8,200 (X=50), 16,000 (X=100), 32,000 (X=200)
Package size

100mg, 500mg, 1g

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