ALK-PLL

Alkyne-Poly(L-Lysine) (Alkyne-PLL)

Price range: $220.00 through $1,260.00

Alkyne-Poly(L-Lysine) (Alkyne-PLL) is an alkyne-functionalized cationic polypeptide composed of poly(L-lysine) with a terminal alkyne group. The alkyne functionality enables efficient click chemistry with azide-containing molecules, while the poly(L-lysine) backbone contains multiple primary amine groups for nucleic acid complexation and chemical modification. Alkyne-PLL is widely used in click chemistry, gene delivery, nanoparticle engineering, hydrogel synthesis, and biomaterials research.

Product Name: Alkyne-Poly(L-Lysine)
Alternative Name: Alkyne-PLL, Alkynyl-Poly(L-Lysine)
Molecular Weight: Custom
Degree of Polymerization: Custom
Functional Groups: Terminal Alkyne, Multiple Primary Amines
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS, aqueous buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

ALK-PLL

 

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SKU: 10998 Categories: , , ,

Description

General Description

Alkyne-Poly(L-Lysine) is a functional cationic polypeptide designed for bioorthogonal conjugation and advanced drug delivery applications. The terminal alkyne group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules, forming stable triazole linkages with excellent efficiency and selectivity.

The poly(L-lysine) backbone contains numerous primary amine groups that readily complex with negatively charged nucleic acids such as DNA, RNA, siRNA, and mRNA. These amine groups also react with NHS esters, activated carboxylic acids, aldehydes, epoxides, and other amine-reactive molecules, providing versatile opportunities for further functionalization.

The combination of a cationic biodegradable polypeptide and a terminal alkyne functionality makes Alkyne-PLL an excellent material for gene delivery, polymer-drug conjugates, click chemistry, nanoparticle functionalization, hydrogel preparation, molecular imaging, and advanced biomaterials research.

Applications

  • Click chemistry (CuAAC)
  • Gene delivery
  • DNA and RNA complexation
  • Protein conjugation
  • Nanoparticle functionalization
  • Surface modification
  • Hydrogel synthesis
  • Drug conjugation
  • Molecular imaging
  • Biomaterials research

Features and Benefits

  • Terminal alkyne functionality
  • Compatible with CuAAC click chemistry
  • Multiple primary amine groups
  • Excellent nucleic acid binding
  • Excellent aqueous solubility
  • Biodegradable polypeptide
  • Suitable for post-polymer functionalization
  • Available in multiple molecular weights

Additional information

Molecular weight

3300(X=20), 8,200 (X=50), 16,000 (X=100), 32,000 (X=200)
Package size

100mg, 500mg, 1g

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