Description
General Description
DOPE-PEG-COOH is a phospholipid–poly(ethylene glycol) conjugate containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, C18:1), a hydrophilic PEG spacer, and a terminal carboxylic acid functional group. The carboxyl group enables versatile conjugation and surface functionalization through amide coupling and esterification reactions.
Key Properties
- Carboxyl-functionalized PEG phospholipid
- Reactive terminal carboxylic acid group
- DOPE phospholipid anchor (C18:1)
- Unsaturated fusogenic lipid structure
- PEG spacer improves aqueous stability and biocompatibility
Applications
- Liposome and lipid nanoparticle functionalization
- Drug and nucleic acid delivery
- Surface modification of nanoparticles and biomaterials
- Biomolecule and polymer conjugation
- Hydrogel and biomaterial engineering
- Targeted nanomedicine applications
Functional Overview
The DOPE lipid segment supports membrane fusion and endosomal escape, while the PEG spacer improves steric stabilization and circulation behavior. The terminal carboxylic acid group enables conjugation with amine-containing molecules through carbodiimide-mediated coupling reactions.
Summary
DOPE-PEG-COOH is a versatile carboxyl-functional PEGylated phospholipid widely used in liposome engineering, nanomedicine, and advanced drug delivery applications.
