Description
General Description
DSPE-PEG-DBCO is a versatile lipid-PEG conjugate designed for membrane anchoring and copper-free click chemistry conjugation. The DSPE lipid anchor readily incorporates into liposomal membranes and lipid nanoparticle formulations, while the PEG spacer extends into the aqueous environment, improving colloidal stability, reducing nonspecific interactions, and enhancing circulation properties.
The terminal DBCO group reacts rapidly and selectively with azide-containing molecules through strain-promoted azide-alkyne cycloaddition (SPAAC) without requiring copper catalysts. This bioorthogonal reaction proceeds efficiently under physiological conditions and is particularly useful for conjugating peptides, proteins, antibodies, nucleic acids, fluorophores, and targeting ligands. DSPE-PEG-DBCO is widely used in liposome engineering, targeted nanomedicine, molecular imaging, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Copper-free click chemistry
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Molecular imaging
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Reactive DBCO group for copper-free click chemistry
- Compatible with azide-containing molecules
- No copper catalyst required
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
