Description
General Description
DSPE-PEG-Iodoacetyl is a functional phospholipid derivative designed for membrane anchoring and thiol-specific bioconjugation. The DSPE segment efficiently inserts into lipid bilayers, liposomes, lipid nanoparticles (LNPs), micelles, and other lipid-based delivery systems. The PEG spacer extends into the aqueous environment, improving colloidal stability, reducing steric hindrance, and minimizing nonspecific interactions.
The terminal iodoacetyl group selectively reacts with sulfhydryl-containing molecules such as cysteine-containing peptides, proteins, antibodies, enzymes, and thiolated nucleic acids to form stable thioether linkages. Compared with maleimide chemistry, iodoacetyl groups can provide highly stable sulfur-carbon bonds and are frequently used in bioconjugation, targeted delivery, and surface engineering applications.
Applications
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Protein conjugation
- Antibody conjugation
- Peptide conjugation
- Thiolated oligonucleotide conjugation
- Surface modification
- Targeted drug delivery
- Nanoparticle engineering
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Reactive iodoacetyl functionality
- Efficient thiol-specific conjugation
- Forms stable thioether linkages
- Hydrophilic PEG spacer
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Available in multiple PEG molecular weights
Reviews
There are no reviews yet.