Description
General Description
DSPE-PEG-Mannose is a functional lipid-PEG conjugate consisting of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), a hydrophilic polyethylene glycol (PEG) spacer, and a terminal mannose ligand.
The hydrophobic DSPE moiety serves as a lipid anchor and enables incorporation of DSPE-PEG-Mannose into liposomes, lipid nanoparticles, micelles, and other lipid-based assemblies. The PEG spacer extends the mannose group away from the lipid surface, improving its accessibility for interactions with mannose-binding receptors.
Mannose is widely investigated as a targeting ligand for mannose receptors (CD206) and other mannose-recognizing lectins. Mannose-functionalized nanocarriers are therefore commonly studied for targeting macrophages, dendritic cells, and other mannose receptor-expressing cells.
DSPE-PEG-Mannose can be incorporated into lipid formulations to introduce mannose functionality without requiring post-formulation conjugation. It is useful for targeted drug and gene delivery, vaccine delivery, immunological research, cellular uptake studies, and development of functional lipid nanoparticles.
Applications
- Mannose receptor-targeted drug delivery
- Macrophage targeting
- Dendritic cell targeting
- Liposome functionalization
- Lipid nanoparticle (LNP) functionalization
- Targeted gene delivery
- Vaccine delivery research
- Cellular uptake studies
- Nanomedicine
- Biomaterials research
Features and Benefits
- DSPE lipid anchor
- Hydrophilic PEG spacer
- Terminal mannose functionality
- Suitable for mannose receptor targeting
- Suitable for macrophage and dendritic cell targeting
- Compatible with liposomes and lipid nanoparticles
- Convenient incorporation into lipid formulations
- Tunable PEG molecular weight
- Custom compositions available
