Description
General Description
HO-PEG-COOtBu is a versatile heterobifunctional PEG building block designed for orthogonal synthetic strategies. The terminal tert-butyl ester-protected carboxyl group remains stable under neutral and basic conditions but can be readily deprotected under acidic conditions (typically trifluoroacetic acid or HCl in dioxane) to yield HO-PEG-COOH.
The terminal hydroxyl group serves as a convenient synthetic handle and can be readily converted into a variety of functional groups, including amine, NHS ester, maleimide, azide, alkyne, aldehyde, acrylate, methacrylate, epoxide, and thiol. This enables the sequential preparation of a broad range of customized PEG derivatives.
The hydrophilic PEG spacer improves water solubility, molecular flexibility, and biocompatibility while reducing steric hindrance and minimizing nonspecific interactions. HO-PEG-COOtBu is widely employed in PEG linker synthesis, polymer chemistry, peptide synthesis, nanoparticle functionalization, targeted drug delivery, and advanced biomaterials development.
Applications
- Polymer synthesis
- PEG linker synthesis
- Peptide synthesis
- Surface modification
- Nanoparticle functionalization
- Drug delivery systems
- Hydrogel synthesis
- Biomaterials engineering
- Organic synthesis
- Biomedical research
Features and Benefits
- Terminal hydroxyl group
- tert-Butyl ester-protected carboxyl group
- Acid-labile protecting group
- Selective deprotection to HO-PEG-COOH
- Excellent water solubility
- Excellent biocompatibility
- Orthogonal functionalization
- Versatile synthetic intermediate
- Available in multiple PEG molecular weights
