Description
General Description
mPEG-Succinic Acid Amide (mPEG-SAA) is a monofunctional PEG carboxylic acid reagent designed for selective bioconjugation and polymer modification. The terminal methoxy group is chemically inert, while the succinic acid amide moiety provides a stable terminal carboxylic acid suitable for amide bond formation after activation.
Following activation with carbodiimide reagents such as EDC/NHS, the terminal carboxyl group efficiently reacts with proteins, peptides, antibodies, amino-containing drugs, polymers, nanoparticles, and other amine-containing molecules to form stable amide linkages.
The PEG spacer improves aqueous solubility, enhances biocompatibility, reduces nonspecific protein adsorption, and prolongs circulation time in vivo. mPEG-SAA is widely used in PEGylation, polymer-drug conjugates, nanoparticle surface modification, hydrogel synthesis, and biomedical research.
Applications
- Protein PEGylation
- Peptide conjugation
- Antibody modification
- Drug conjugation
- Polymer synthesis
- Nanoparticle functionalization
- Surface modification
- Hydrogel synthesis
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Linear monofunctional PEG carboxylic acid
- Terminal succinic acid amide functionality
- Reactive terminal carboxylic acid
- Compatible with EDC/NHS activation
- Stable amide linker
- Excellent water solubility
- Excellent biocompatibility
- Available in multiple PEG molecular weights
