Description
General Description
mPEG-Succinimide Acid Succinimidyl Ester (mPEG-SAS) is a highly reactive linear monofunctional PEG reagent designed for efficient amine-selective bioconjugation. The terminal methoxy group is chemically inert, preventing polymer crosslinking, while the succinimide acid succinimidyl ester (SAS) group serves as an activated carboxyl functionality for rapid coupling with primary amines.
The activated succinimidyl ester reacts efficiently with proteins, peptides, antibodies, enzymes, amino-containing polymers, nanoparticles, and other biomolecules under mild aqueous conditions (typically pH 7.2–8.5), forming stable amide bonds. The succinimide acid spacer provides flexibility between the PEG chain and the conjugated molecule, helping reduce steric hindrance and improve coupling efficiency.
The PEG spacer enhances aqueous solubility, improves biocompatibility, reduces nonspecific protein adsorption, and prolongs circulation time in vivo. mPEG-SAS is widely used for therapeutic protein PEGylation, antibody modification, polymer synthesis, nanoparticle surface engineering, hydrogel fabrication, and advanced biomedical research.
Applications
- Protein PEGylation
- Peptide conjugation
- Antibody modification
- Enzyme conjugation
- Drug conjugation
- Nanoparticle functionalization
- Surface modification
- Hydrogel synthesis
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Linear monofunctional PEG reagent
- Activated succinimidyl ester
- Rapid amine-selective conjugation
- Stable amide bond formation
- Excellent coupling efficiency
- Excellent water solubility
- Excellent biocompatibility
- Available in multiple PEG molecular weights
