Description
General Description
Nδ-Carbobenzyloxy-L-Ornithine N-Carboxyanhydride (Z-Orn-NCA) is a high-purity amino acid NCA monomer designed for controlled ring-opening polymerization to produce well-defined poly(Nδ-carbobenzyloxy-L-ornithine). The N-carboxyanhydride ring polymerizes efficiently in the presence of primary amine initiators, allowing excellent control over molecular weight and polymer architecture.
The δ-amino side chain is protected with a carbobenzyloxy (Cbz or Z) group during polymerization to prevent undesired side reactions. Following polymerization, the protecting groups can be removed by catalytic hydrogenation to produce poly(L-ornithine), a biodegradable cationic polypeptide containing primary amine side chains.
Poly(L-ornithine) exhibits excellent biocompatibility and strong electrostatic interactions with nucleic acids, making it an attractive material for gene delivery, mRNA and siRNA delivery, nanoparticle preparation, tissue engineering, and surface modification.
Applications
- Ring-opening polymerization (ROP)
- Poly(L-ornithine) synthesis
- Block copolymer synthesis
- Gene delivery research
- DNA delivery
- mRNA and siRNA delivery
- Nanoparticle preparation
- Tissue engineering
- Surface modification
- Biomaterials research
Features and Benefits
- High-purity NCA monomer
- Efficient ring-opening polymerization
- Carbobenzyloxy-protected side-chain amine
- Controlled molecular weight synthesis
- Suitable for living polymerization
- Excellent polymerization activity
- Precursor to poly(L-ornithine)
- Research-grade quality
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