Description
General Description
N6-Carbobenzoxy-L-lysine N-Carboxyanhydride (Z-L-Lys NCA) is a high-purity α-amino acid N-carboxyanhydride (NCA) derived from N6-carbobenzoxy-L-lysine. The ε-amino side chain is protected with a carbobenzoxy (Cbz, Z) group, preventing undesired side reactions during ring-opening polymerization while maintaining excellent monomer reactivity.
The monomer readily undergoes controlled ring-opening polymerization using primary amines, organocatalysts, transition metal initiators, or macroinitiators such as PEG-NH₂ to produce well-defined poly(Nε-carbobenzoxy-L-lysine) (PZLL). Following polymerization, the Cbz protecting groups can be removed by catalytic hydrogenation or other suitable deprotection methods to generate poly(L-lysine) (PLL) containing free ε-amino groups for further functionalization.
Z-L-Lys NCA is widely employed for synthesizing biodegradable polypeptides, block copolymers, gene delivery vectors, peptide-polymer conjugates, drug delivery systems, hydrogels, and advanced biomaterials.
Applications
- Ring-opening polymerization (ROP)
- Poly(L-lysine) precursor synthesis
- PEG-polypeptide block copolymer synthesis
- Drug delivery systems
- Gene delivery vectors
- Hydrogel preparation
- Tissue engineering
- Nanoparticle fabrication
- Protein and peptide conjugates
- Biomaterials research
Features and Benefits
- High-purity NCA monomer
- Carbobenzoxy (Cbz, Z) protected ε-amino group
- Excellent polymerization reactivity
- Enables controlled polypeptide synthesis
- Compatible with living ROP
- Produces well-defined lysine-based polymers
- Suitable for biodegradable polymer synthesis
- Research-grade quality
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