Trityl-S-PLL

Tritylthiol-Terminated Poly(L-Lysine) (Trt-PLL)

Price range: $260.00 through $1,260.00

Tritylthiol-Terminated Poly(L-Lysine) (Trt-PLL) is a biodegradable poly(L-lysine) derivative containing a terminal trityl-protected thiol (Trt-SH) group. The trityl group protects the thiol during synthesis and storage and can be readily removed under mild acidic conditions to generate a free thiol for subsequent bioconjugation. Trt-PLL is widely used in gene delivery, polymer synthesis, hydrogel preparation, nanoparticle functionalization, and biomaterials research.

Product Name: Tritylthiol-Terminated Poly(L-Lysine)
Alternative Name: Trt-PLL, Trt-SH-PLL, Trityl-Protected Thiol-Poly(L-Lysine)
Molecular Weight: Custom
Degree of Polymerization: Custom
Functional Groups: Terminal Trityl-Protected Thiol (Trt-SH), Multiple Primary Amines
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS, aqueous buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

Trityl-S-PLL

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SKU: 11028 Categories: , , ,

Description

General Description

Tritylthiol-Terminated Poly(L-Lysine) is a functional polypeptide designed as a protected thiol intermediate for advanced biomaterials and drug delivery applications. The terminal thiol is protected with a trityl (Trt) group, preventing premature oxidation and disulfide formation while providing excellent stability during synthesis and storage.

Following deprotection, the resulting thiol-functionalized poly(L-lysine) readily participates in thiol-maleimide conjugation, thiol-ene click chemistry, Michael addition, disulfide bond formation, and gold surface immobilization.

The poly(L-lysine) backbone contains multiple primary amine groups that enable electrostatic complexation with DNA, RNA, siRNA, and mRNA, as well as conjugation with NHS esters, activated carboxylic acids, aldehydes, and other amine-reactive molecules. Trt-PLL is widely employed in gene delivery, polymer-drug conjugates, hydrogel synthesis, nanoparticle engineering, tissue engineering, and advanced biomaterials research.

Applications

  • Gene delivery
  • DNA and RNA complexation
  • Thiol-functional polymer synthesis
  • Nanoparticle functionalization
  • Hydrogel synthesis
  • Protein conjugation
  • Surface modification
  • Gold nanoparticle functionalization
  • Tissue engineering
  • Biomaterials research

Features and Benefits

  • Terminal trityl-protected thiol
  • Easily deprotected to free thiol
  • Multiple primary amines on PLL
  • Excellent nucleic acid binding
  • Excellent water solubility
  • Biodegradable polypeptide
  • Suitable for post-polymer functionalization
  • Available in multiple molecular weights

Additional information

Molecular weight

3300(X=20), 8,200 (X=50), 16,000 (X=100), 32,000 (X=200)
Package size

100mg, 500mg, 1g

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