Description
General Description
4-Arm PEG-SG is a highly reactive branched PEG derivative designed for amine-specific bioconjugation and hydrogel formation. Compared with linear PEG derivatives, the four-arm architecture provides higher functional group density, enhanced crosslinking efficiency, and increased loading capacity for biomolecules and therapeutic agents.
The terminal succinimidyl glutarate ester groups react efficiently with primary amines on proteins, peptides, antibodies, enzymes, and biomaterial surfaces to form stable amide bonds. The glutarate spacer introduces additional flexibility compared with SCM derivatives and is frequently utilized in protein PEGylation and hydrogel fabrication.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and resistance to nonspecific protein adsorption. 4-Arm PEG-SG is widely employed in protein modification, tissue engineering, drug delivery systems, cell encapsulation, hydrogel preparation, and advanced biomaterials development.
Applications
- Protein PEGylation
- Antibody conjugation
- Peptide conjugation
- Hydrogel synthesis
- Injectable hydrogels
- Tissue engineering
- Cell encapsulation
- Drug delivery systems
- Surface modification
- Biomaterials research
Features and Benefits
- Four terminal SG ester groups
- Highly reactive toward primary amines
- Multi-arm PEG architecture
- Efficient amine-specific conjugation
- Flexible glutarate spacer
- Excellent water solubility
- Excellent biocompatibility
- Low protein adsorption
- Available in multiple molecular weights
