Description
General Description
4-Arm PEG-Succinimidyl Succinate Ester is a highly reactive branched PEG derivative designed for amine-specific bioconjugation and hydrogel formation. Compared with linear PEG derivatives, the four-arm architecture provides higher functional group density, enhanced crosslinking efficiency, and increased loading capacity for biomolecules and therapeutic agents.
The terminal NHS ester groups readily react with primary amines on proteins, peptides, antibodies, enzymes, and biomaterial surfaces to form stable amide bonds. The succinimidyl succinate spacer provides a biodegradable ester linkage, making this material attractive for controlled-release and biodegradable biomaterials applications.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and resistance to nonspecific protein adsorption. 4-Arm PEG-SS is frequently employed in protein PEGylation, hydrogel fabrication, tissue engineering, cell encapsulation, and drug delivery applications.
Applications
- Protein PEGylation
- Antibody conjugation
- Peptide conjugation
- Hydrogel synthesis
- Injectable hydrogels
- Tissue engineering
- Cell encapsulation
- Drug delivery systems
- Surface modification
- Biomaterials research
Features and Benefits
- Four terminal NHS ester groups
- Highly reactive toward primary amines
- Multi-arm PEG architecture
- High crosslinking efficiency
- Efficient protein conjugation
- Excellent water solubility
- Excellent biocompatibility
- Low protein adsorption
- Available in multiple molecular weights
