Description
General Description
Alkyne-PEG-Maleimide (ALK-PEG-MAL) is a versatile heterobifunctional PEG linker designed for sequential and orthogonal conjugation strategies. The terminal alkyne group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and can also be used in selected bioorthogonal click chemistry applications. The terminal maleimide group reacts rapidly and selectively with sulfhydryl (thiol) groups on cysteine-containing peptides, proteins, antibodies, and other biomolecules under mild aqueous conditions to form stable thioether linkages.
The hydrophilic PEG spacer improves water solubility, molecular flexibility, and biocompatibility while reducing nonspecific protein adsorption. The combination of alkyne and maleimide functionalities allows two independent conjugation reactions, making Alkyne-PEG-Maleimide an ideal linker for constructing multifunctional biomolecules, antibody-drug conjugates, nanoparticle surface modifications, imaging probes, and targeted therapeutic systems.
Applications
- Click chemistry conjugation
- Thiol-specific conjugation
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Nanoparticle functionalization
- Hydrogel synthesis
- Drug delivery systems
- Molecular imaging
- Biomaterials research
Features and Benefits
- Heterobifunctional PEG linker
- Terminal alkyne group
- Terminal maleimide group
- Compatible with CuAAC click chemistry
- Highly selective thiol conjugation
- Forms stable thioether bonds
- Excellent water solubility
- Excellent biocompatibility
- Available in multiple PEG molecular weights
