Description
General Description
DOPC is a synthetic phosphatidylcholine widely used in pharmaceutical, biochemical, and biophysical research. The molecule consists of two cis-oleoyl (18:1) fatty acid chains attached to a glycerophosphocholine backbone, producing fluid lipid bilayers at physiological temperatures.
Because of its low gel-to-liquid crystalline phase transition temperature, DOPC readily forms stable and highly fluid lipid membranes, making it one of the most frequently used phospholipids for liposome preparation, supported lipid bilayers, giant unilamellar vesicles (GUVs), and artificial cell membrane models.
DOPC is commonly combined with cholesterol, PEGylated lipids, ionizable lipids, and other phospholipids to prepare lipid nanoparticles, liposomes, and nanocarriers for drug delivery, nucleic acid delivery, molecular imaging, and membrane interaction studies.
Applications
- Liposome preparation
- Lipid nanoparticle (LNP) formulation
- Artificial membrane models
- Supported lipid bilayers
- Giant unilamellar vesicles (GUVs)
- Drug delivery systems
- Membrane protein studies
- Nanomedicine research
- Molecular imaging
- Biomaterials research
Features and Benefits
- High-purity synthetic phospholipid
- Unsaturated C18:1 lipid chains
- Excellent membrane fluidity
- Forms stable lipid bilayers
- Biocompatible phosphatidylcholine
- Suitable for liposomes and LNPs
- Low phase transition temperature
- Widely used in membrane research
