Description
General Description
DSPC is a zwitterionic phosphatidylcholine lipid composed of two saturated stearic acid (C18:0) chains attached to a glycerophosphocholine backbone. The fully saturated hydrocarbon chains give DSPC a high gel-to-liquid crystalline phase transition temperature (Tm approximately 55°C), resulting in excellent membrane rigidity and stability.
DSPC is extensively employed as a structural phospholipid in liposomes and lipid nanoparticles, where it improves particle integrity, reduces membrane leakage, and enhances in vivo stability. It has become one of the standard helper lipids used in lipid nanoparticle formulations for mRNA therapeutics and vaccines.
DSPC is compatible with cholesterol, PEG-lipids, and ionizable or cationic lipids, making it suitable for the preparation of long-circulating liposomes, lipid nanoparticles, targeted delivery systems, and sustained-release formulations.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) formulation
- mRNA delivery
- siRNA delivery
- Vaccine development
- Drug delivery
- Membrane studies
- Nanomedicine
- Pharmaceutical formulation
- Biomedical research
Features and Benefits
- High-purity phosphatidylcholine lipid
- Fully saturated C18 lipid chains
- Excellent membrane stability
- High phase transition temperature (~55°C)
- Low membrane permeability
- Excellent biocompatibility
- Compatible with cholesterol and PEG-lipids
- Widely used in LNP and liposome formulations
- Suitable for GMP and pharmaceutical development
