Description
General Description
DSPE-Biotin is a biotin-functionalized lipid designed for preparing affinity-based lipid membranes and nanoparticle systems. The DSPE lipid anchor consists of two saturated stearoyl (C18:0) hydrocarbon chains that insert efficiently into lipid bilayers, providing excellent membrane stability.
The terminal biotin moiety binds strongly to streptavidin and avidin (Kd ≈ 10⁻¹⁵ M), enabling versatile affinity interactions for the immobilization or attachment of proteins, antibodies, peptides, nucleic acids, targeting ligands, and imaging probes.
DSPE-Biotin allows convenient surface modification of liposomes, lipid nanoparticles, supported lipid bilayers, and other lipid-based materials. It is widely employed for streptavidin-mediated conjugation, targeted drug delivery, biosensor fabrication, cell membrane studies, molecular imaging, and advanced nanomedicine applications.
Applications
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Streptavidin-mediated conjugation
- Protein attachment
- Antibody immobilization
- Biosensor fabrication
- Molecular imaging
- Targeted drug delivery
- Supported lipid bilayers
- Biomaterials research
Features and Benefits
- High-affinity biotin functionality
- Stable DSPE lipid anchor
- Strong streptavidin/avidin binding
- Efficient membrane incorporation
- Suitable for liposomes and LNPs
- Enables affinity-based modification
- Useful for targeting applications
- Biocompatible lipid material
