Description
General Description
DSPE-Glutaric Acid is a carboxyl-functionalized phospholipid designed for the preparation of functional lipid-based delivery systems. The DSPE moiety contains two saturated stearoyl (C18:0) hydrocarbon chains that readily insert into lipid bilayers, liposomes, and lipid nanoparticles, providing excellent membrane stability.
The terminal glutaric acid spacer introduces a reactive carboxyl group that can be activated using carbodiimide chemistry (EDC/NHS) or other peptide-coupling reagents for conjugation with proteins, peptides, antibodies, amine-containing drugs, polymers, nanoparticles, and targeting ligands. The glutaric acid linker also provides additional spacing between the lipid membrane and conjugated biomolecules, improving accessibility and reducing steric hindrance.
DSPE-Glutaric Acid is widely employed in targeted liposome preparation, lipid nanoparticle surface modification, biosensor fabrication, molecular imaging, and advanced nanomedicine applications.
Applications
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Protein conjugation
- Antibody conjugation
- Peptide attachment
- Drug delivery systems
- Surface modification
- Biosensor fabrication
- Molecular imaging
- Biomaterials research
Features and Benefits
- Terminal glutaric acid functionality
- Reactive carboxylic acid group
- Compatible with EDC/NHS coupling
- Stable DSPE lipid anchor
- Efficient membrane incorporation
- Suitable for liposomes and LNPs
- Improved ligand accessibility
- Biocompatible phospholipid
