Description
General Description
DSPE-pSar-Biotin is a functional lipid-polypeptoid conjugate designed for membrane anchoring, nanoparticle stabilization, and streptavidin-mediated bioconjugation. The DSPE lipid anchor readily incorporates into liposomal membranes, lipid nanoparticles (LNPs), and other lipid-based delivery systems, while the polysarcosine chain extends into the aqueous environment, creating a hydrophilic stealth layer that minimizes protein adsorption and nonspecific interactions.
The terminal biotin group provides exceptionally strong and specific binding to streptavidin, avidin, and neutravidin. This interaction enables efficient attachment of biomolecules, imaging probes, antibodies, proteins, and targeting ligands. DSPE-pSar-Biotin combines the stealth properties of polysarcosine with the versatility of biotin-streptavidin technology, making it useful for targeted drug delivery, diagnostics, biosensing, and advanced nanomedicine applications.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Targeted drug delivery
- Protein immobilization
- Antibody conjugation
- Streptavidin-mediated targeting
- Diagnostic assay development
- Biosensor development
- Surface modification
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Polysarcosine stealth polymer coating
- Biotin functionality for streptavidin binding
- Low protein adsorption
- Low immunogenicity
- Alternative to PEGylated lipids
- Improves nanoparticle stability
- Strong avidin/streptavidin affinity
- Suitable for liposomes and LNPs
- Excellent biocompatibility
