Description
General Description
DSPE-pSar-N3 is a functional lipid-polypeptoid conjugate designed for membrane anchoring, nanoparticle stabilization, and click chemistry conjugation. The DSPE lipid anchor readily incorporates into liposomal membranes, lipid nanoparticles (LNPs), and other lipid-based delivery systems, while the polysarcosine chain extends into the aqueous environment, creating a hydrophilic stealth layer that minimizes protein adsorption and nonspecific interactions.
The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with alkyne- and DBCO-functionalized molecules. DSPE-pSar-N3 combines the stealth properties of polysarcosine with bioorthogonal click chemistry, making it an attractive alternative to PEGylated lipids for targeted nanomedicine, molecular imaging, and advanced drug delivery applications.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Click chemistry conjugation
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Molecular imaging
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Polysarcosine stealth polymer coating
- Reactive azide group for click chemistry
- Compatible with CuAAC and SPAAC reactions
- Low protein adsorption
- Low immunogenicity
- Alternative to PEGylated lipids
- Improves nanoparticle stability
- Suitable for liposomes and LNPs
- Excellent biocompatibility
