Poly(L-Ornithine)-PEG-N3 structure

Poly(L-Ornithine)-PEG-N3

Price range: $460.00 through $1,800.00

Poly(L-Ornithine)-PEG-N3 is a functional graft copolymer consisting of poly(L-ornithine) (PLO) modified with polyethylene glycol (PEG) terminated with azide (N3) groups. The cationic poly(L-ornithine) backbone enables efficient interaction with nucleic acids and negatively charged biomolecules, while PEG improves biocompatibility and colloidal stability. The terminal azide functionality provides a versatile handle for click chemistry conjugation. Poly(L-Ornithine)-PEG-N3 is widely used in gene delivery, nanoparticle engineering, targeted drug delivery, tissue engineering, and biomaterials research.

Product Specifications

Product Name: Poly(L-Ornithine)-PEG-N3
Polymer Composition: Poly(L-Ornithine)-graft-Polyethylene Glycol Azide
Poly(L-Ornithine) Molecular Weight: 2K, 5k, 10k, Custom
PEG Molecular Weight: 2000, 3400, 5000 Da, Custom
PEG Substitution: Customizable
Functional Groups: Poly(L-Ornithine), PEG, Azide (N3)
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS, DMSO
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

Poly(L-Ornithine)-PEG-N3 structure

 

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SKU: 96138 Categories: , ,

Description

General Description

Poly(L-Ornithine)-PEG-N3 is a multifunctional polypeptide copolymer designed for advanced bioconjugation and drug delivery applications. The poly(L-ornithine) backbone contains multiple primary amine groups that readily complex DNA, mRNA, siRNA, proteins, and other negatively charged biomolecules through electrostatic interactions.

PEG grafting improves aqueous solubility, reduces nonspecific protein adsorption, enhances colloidal stability, and decreases the cytotoxicity commonly associated with highly cationic polymers. The terminal azide groups enable efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) for attachment of antibodies, peptides, fluorophores, targeting ligands, nanoparticles, and imaging probes.

Poly(L-Ornithine)-PEG-N3 is widely employed in gene delivery systems, nanoparticle functionalization, hydrogel preparation, tissue engineering, molecular imaging, and advanced biomaterials development.

Applications

  • Gene delivery
  • DNA transfection
  • mRNA delivery
  • siRNA delivery
  • Click chemistry conjugation
  • Nanoparticle functionalization
  • Surface modification
  • Tissue engineering
  • Hydrogel synthesis
  • Biomaterials research

Features and Benefits

  • Cationic poly(L-ornithine) backbone
  • Reactive azide functionality
  • Compatible with CuAAC and SPAAC chemistry
  • Improved aqueous solubility
  • Reduced cytotoxicity through PEGylation
  • Excellent biocompatibility
  • Strong nucleic acid binding capability
  • Suitable for targeted delivery
  • Available with customizable PEG substitution

Additional information

pOrn molecular weight

2000, 5000, 10K
PEG molecular weight

2000, 5000
package size

100mg, 500mg, 1g

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