Description
General Description
DSPE-pSar-Mal is a functional lipid-polypeptoid conjugate designed for membrane anchoring, nanoparticle stabilization, and thiol-specific bioconjugation. The DSPE lipid anchor readily incorporates into liposomal membranes, lipid nanoparticles (LNPs), and other lipid-based delivery systems, while the polysarcosine chain extends into the aqueous environment, creating a hydrophilic stealth layer that minimizes protein adsorption and nonspecific interactions.
The terminal maleimide group selectively reacts with thiol-containing peptides, proteins, antibodies, aptamers, and other biomolecules under mild conditions to form stable thioether linkages. DSPE-pSar-Mal combines the stealth properties of polysarcosine with highly efficient bioconjugation chemistry, making it an attractive alternative to PEGylated lipids for advanced drug delivery and nanomedicine applications.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Thiol-maleimide bioconjugation
- Surface modification
- mRNA delivery systems
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Polysarcosine stealth polymer coating
- Reactive maleimide group for thiol conjugation
- Forms stable thioether linkages
- Low protein adsorption
- Low immunogenicity
- Alternative to PEGylated lipids
- Improves nanoparticle stability
- Suitable for liposomes and LNPs
