Description
General Description
HS-PEG-OH is a versatile heterobifunctional PEG linker designed for orthogonal functionalization and surface engineering. The terminal thiol group reacts rapidly and selectively with maleimides to form stable thioether linkages. It also participates in thiol-ene reactions, disulfide exchange, Michael addition, and readily self-assembles onto gold nanoparticles and gold-coated surfaces through strong gold-sulfur interactions.
The terminal hydroxyl group provides a convenient site for further derivatization into carboxyl, amine, NHS ester, aldehyde, azide, alkyne, acrylate, methacrylate, and numerous other functional PEG derivatives.
The hydrophilic PEG spacer enhances water solubility, molecular flexibility, and biocompatibility while reducing nonspecific protein adsorption. HS-PEG-OH is widely employed in biosensor fabrication, nanoparticle engineering, surface PEGylation, hydrogel synthesis, molecular imaging, and targeted drug delivery.
Applications
- Gold nanoparticle functionalization
- Gold surface modification
- Surface PEGylation
- Thiol-maleimide conjugation
- Biosensor fabrication
- Nanoparticle engineering
- Hydrogel synthesis
- Drug delivery systems
- Polymer synthesis
- Biomaterials research
Features and Benefits
- Heterobifunctional PEG linker
- Reactive terminal thiol group
- Reactive terminal hydroxyl group
- Suitable for gold surface immobilization
- Compatible with thiol-maleimide chemistry
- Excellent water solubility
- Excellent biocompatibility
- Low nonspecific protein adsorption
- Available in multiple PEG molecular weights
