Description
General Description
MPEG-OH is one of the most widely used monofunctional PEG materials in polymer chemistry, pharmaceutical development, and biomaterials research. The molecule contains one non-reactive methoxy terminus and one reactive hydroxyl terminus, allowing controlled single-end functionalization.
The terminal hydroxyl group can be converted into various functional groups, including carboxyl, amine, NHS ester, maleimide, azide, alkyne, thiol, acrylate, methacrylate, and aldehyde groups. MPEG-OH is commonly used as a starting material for the synthesis of functional MPEG derivatives such as MPEG-NH2, MPEG-COOH, MPEG-MAL, MPEG-N3, MPEG-SH, and MPEG-lipid conjugates.
MPEG-OH is also widely used as a macroinitiator for ring-opening polymerization (ROP) to prepare amphiphilic block copolymers such as MPEG-PLA, MPEG-PLGA, MPEG-PCL, and other biodegradable PEG-polyester materials. The hydrophilic PEG segment improves water solubility, biocompatibility, and steric stabilization of nanoparticles and drug delivery systems.
Applications
- PEGylation reagent synthesis
- Functional PEG precursor
- Polymer synthesis
- Ring-opening polymerization initiator
- Block copolymer synthesis
- Nanoparticle formulation
- Drug delivery systems
- Hydrogel preparation
- Surface modification
- Biomaterials research
Features and Benefits
- Monofunctional PEG structure
- Terminal hydroxyl functionality
- Methoxy-capped PEG end
- Controlled single-end modification
- Excellent water solubility
- Excellent biocompatibility
- Low nonspecific interactions
- Versatile PEG intermediate
- Available in multiple molecular weights
